英國布裏斯托爾大學等機構研究人員在新一期美國《臨床藥理學與治療學》雜志上報告說，他們對６名多發性硬化症患者進行了這項試驗。研究人員在病 人麻醉狀況下抽取他們的骨髓幹細胞，經過處理後，注射到病人的靜脈中。隨後一年的觀察顯示，病人沒有出現嚴重的不良反應，而多發性硬化症的症狀也有所改 善。
Bone marrow stem cell therapy offers hope to multiple sclerosis patients
The Bristol team report on this pioneering trial in an article published online in Clinical Pharmacology and Therapeutics.
The paper, 'Safety and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis' was performed at the Institute of Clinical Neurosciences, Frenchay Hospital, Bristol and the Bristol Haematology and Oncology Centre.
The study explored the safety and feasibility of cell therapy in patients with MS. Participants had a general anaesthetic during which bone marrow was harvested. The marrow cells were filtered and prepared so that they could be injected into the patient's vein later the same day.
The procedure was well tolerated and the participants were followed up for a year. No serious adverse effects were encountered. The results of clinical scores were consistent with stable disease. The results of neurophysiological tests raised the possibility of benefit.
Professor Neil Scolding said: "We are encouraged by the results of this early study. The safety data are reassuring and the suggestion of benefit tantalising. A larger study is required to assess the effectiveness of bone marrow cellular therapy in treating MS. We are hopeful that recruitment to this phase 2/3 study may begin towards the end of this year.
"Research into the underlying mechanisms is ongoing and vital, in order to build on these results. We believe that stem cells mobilised from the marrow to the blood are responsible, and that they help improve disease in several ways, including neuroprotection and immune modulation."