They told him don't you ever
come around here
Don't wanna see your face,
you better disappear
The fire's in their eyes and
their words are really clear
So beat it, just beat it (1:你就閃吧，閃就是了, 閃MS或壓力越遠越好; 2: 擊敗MS, 對抗它)
You better run, you better do (你最好離開/跑開, 或者是盡你所能的去做)
what you can
Don't wanna see no blood,
Don't be a macho man (別當一個逞強的莽夫)
You wanna be tough, (你想要變強悍, 那就盡你所能的去做)
better do what you can
So beat it, (那就 閃吧 或 擊敗MS, 對抗它)
but you wanna be bad (但是不要變壞喔)
*Just beat it, beat it,
beat it, beat it,
No one wants to be defeated, (在這場對抗中,沒有人想要被打敗, 所以展現你的韌性和堅強吧)
Showin' how funky and strong
is your fight
It doesn't matter who's (這樣的遭遇沒有公平正義或誰對誰錯,不用抱怨)
wrong or right
Just beat it, beat it (就 閃吧 或 擊敗MS, 對抗它)
Just beat it, beat it
Just beat it, beat it
Just beat it, beat it
They're out to get you, (MS要來抓你, 你最好盡你所能的離開)
better leave while you can
Don't wanna be a boy,
you wanna be a man
You wanna stay alive, (在這場對抗中,你若想要生存下去, 就盡你所能的去做)
better do what you can
So beat it, just beat it (就 閃吧 或 擊敗MS, 對抗它)
You have to show them that (你已經證明了你並不害怕MS)
you're really not scared
You're playin' with your life, (但是不要虛度光陰)
this ain't no truth or dare
They'll kill you,
then they beat you
Then they'll tell you
it's fair
So beat it,
but you wanna be bad
(Repeat*)
July 23 (Bloomberg) -- Merck KGaA asked European regulators to approve its pill for multiple sclerosis, the next step in the German drugmaker’s race against Novartis AG to market the first oral medicine for the debilitating nerve disease.
同時還有另外一家藥廠Novartis AG 也有同樣的動作, 兩家在競爭誰會成為歐洲第一家MS口服藥物的上市.
Merck submitted a marketing authorization application for the pill, cladribine, to the European Medicines Agency and plans an application to U.S. regulators this quarter, the Darmstadt, Germany-based maker of drugs and chemicals said in an e-mailed statement today.'
默克藥廠的多發性硬化症的口服藥 名稱是: cladribine
Novartis 藥廠的多發性硬化症的口服藥 名稱是: FTY720
The application “brings us closer to the possibility of providing an oral short-course treatment to patients with multiple sclerosis,” Roberto Gradnik, an executive vice president in Merck’s Serono division, said in the statement.
Merck presented clinical trial data at the American Academy of Neurology conference in April showing that cladribine halved the risk of relapse, with a side effect in some patients of depleting the white blood cells that protect the body from infection. Patients who took cladribine were less likely to see their multiple sclerosis progress and more likely not to relapse at all than those on a placebo, the two-year trial showed.
Five people were diagnosed with cancer, including one case of choriocarcinoma, a cancer of the placenta, in a woman who became pregnant six months after she finished the study.
Unlike existing injected medicines for multiple sclerosis, cladribine, approved to fight leukemia more than a decade ago, is taken for a few weeks out of the year in pill form. The medicine works by suppressing the immune system, blunting its attack on nerve cells. Merck’s pill could compete with an experimental pill from Novartis, FTY720, which disrupts the movement of immune cells into the bloodstream.
cladribine 是一種已經核准用來治療白血病(血癌)的藥物, 此藥物藉由壓制免疫系統來避免免疫系統攻擊神經系統的結果, 其結果能夠和FTY720的實驗結果相比擬. 能夠降低MS發作幾乎達到一半的機率, 其副作用是造成血液中白血球的降低
而FTY720主要的作用是破壞或避免免疫細胞進入血液當中(或者是將進入血液當中的免疫細胞予以破壞分解).
Before I knew anything about the disease, when I heard "Multiple Sclerosis," I thought of the Jerry Lewis kids in wheelchairs. No, that's Muscular Dystrophy, but I didn't know.
Right now, I have to be careful walking up or down stairs, holding the handrail to keep my balance. I have lost my vision in my right eye once, for a few days, which struck while on a Los Angeles freeway, and in a panic called my neurologist who knocked it out with an intense steroid shot.
多發性硬化症是一種免疫系統錯誤攻擊自身機體的自體免疫疾病，根據病損部位不同，多發性硬化症可引起人體多種功能障礙。
美國波士頓醫學院的研究人員在7月刊的《神經病學文獻》上報告說，他們對1465名多發性硬化症患者進行了調查。被調查者平均年齡42歲，患病平均時間為9．4年。他們當中的257人現在仍然吸煙，428人曾經吸煙但後來戒煙，780人從不吸煙。
調查開始時，吸煙患者的多發性硬化症病情就已經比其他兩組人嚴重。隨後，研究人員平均每隔3年對調查者進行一次回訪，以確定他們多發性硬化症的發展情況。結果發現，與其他兩組人相比，吸煙患者的多發性硬化症的病情出現惡化的概率最高。
研究人員由此得出結論，吸煙會加劇多發性硬化症的病情。
MONDAY, July 13 (HealthDay News) -- In addition to the well-known hazards of smoking, research now suggests that the dangerous habit causes a more rapid progression of multiple sclerosis.
The new findings are from a study that included 1,465 multiple sclerosis (MS) patients, average age 42, who had had MS for an average of 9.4 years. There were 257 current smokers, 428 past smokers and 780 participants who had never smoked.
At the start of the study, current smokers had significantly more severe disease and were also more likely to have primary progressive MS (a steady decline in health status), rather than relapsing-remitting MS (alternating periods with and without symptoms).
The Boston researchers tracked a group of 891 patients for an average of three years to identify how many changed from relapsing-remitting MS to secondary progressive MS, which is a steady decline that develops after a period of relapsing-remitting MS. During the follow-up, this change was seen in 20 of 154 smokers, 20 of 237 ex-smokers and 32 of 500 never-smokers.
"The conversion from relapsing-remitting MS to secondary progressive MS occurred faster in current smokers compared with never-smokers, but was similar in ex-smokers and never-smokers," according to Brian C. Healy of Brigham and Women's Hospital, Harvard Medical School and Massachusetts General Hospital, and colleagues.
The study was reported in the July issue of Archives of Neurology.
The findings "support the hypothesis that cigarette smoking has an adverse effect on progression of MS as measured by clinical and MRI outcomes," the study authors concluded. "Although causality remains to be proved, these findings suggest that patients with MS who quit smoking may not only reduce their risk of smoking-related diseases but also delay the progression of MS."
I'm bringing up these articles again to remind us that, even though it is that time of year, there are some things we can do to keep functioning the best we can. It is also to remind us that, if we feel a little slower, a little bit MSier, forget and drop things more, not to be too hard on ourselves. Get a glass of iced tea, get in the pool or inside and take it easy.
即使如此, 我們還是要找到讓我清涼一夏的方法, 保持正常, 去喝杯冰水吧, 或者是泡一泡游泳池~
以下文章可以進一步閱讀:
1. MS病患對於熱的容忍度(這個一定要看) 因為天氣熱很有可能讓症狀更明顯!!
2. 10大MS降溫產品
3, 對抗熱浪的小秘訣
4. 自己來做讓MS可以忍受熱的東西~
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