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推薦頻道:Gimmy a break

2015年3月3日 星期二

盼望已久的另一道曙光:幹細胞治療 from UK

Dancing, walking and running again, the wheelchair-bound MS patients after they were given 'miraculous' stem cell treatment

  • Pioneering treatment has allowed wheelchair-bound patients to run again
  • Patient given high dose of chemotherapy to wipe out faulty immune system
  • Therapy then uses person's own stem cells to fight the devastating disease
  • It may be the first ever treatment to successfully reverse symptoms of MS
  • 是目前完全逆轉回復的首例治療方式
Britons left wheelchair-bound by multiple sclerosis can walk, run and even dance again after being given a pioneering stem cell treatment.
Doctors have described the recoveries as ‘miraculous’, while patients say they have been given their lives back.
The treatment uses a patient’s own stem cells – the body’s master cells – to fight the disease. 

Professor Basil Sharrack, of the Royal Hallamshire Hospital in Sheffield, said: ‘Since we started treating patients some three years ago some of the results have been miraculous. 


Today, Holly Drewery(主角) can run after her daughter Isla. Two years ago she could take her for a walk only if someone pushed her wheelchair while she held on to Isla’s pushchair.
2年前Holly Drewery只能坐著輪椅抱著她女兒

Miss Drewery, 25, of Sheffield, pictured with Isla, was diagnosed with MS after suffering numbness and blurred vision. She became wheelchair-bound after her health worsened on Isla’s birth. She needed help with basic tasks and couldn’t even wiggle her toes.

Three weeks after the stem cell transplant she was able to walk out of hospital. 
Now, more than 18 months on, she is almost back to normal. She has a part-time office job and, although she still gets tired, can dance, run and chase after Isla, two, in the park. 

She said: ‘All I wanted to be able to do is take Isla out. It worked wonders. I am more or less back to normal.’

Sam Ramsey collapsed when out celebrating her 22nd birthday and six weeks later was paralysed from the neck down by MS.

另一位患者:Sam Ramsey在她22歲生日後6周,因為MS造成她頸部以下癱瘓。

Other treatments failed but now, after the stem cell treatment, Miss Ramsey, 25, of Newark in Nottinghamshire, can walk on crutches, has passed her driving test and ordered a car.
Sam Ramsey試過很多其它的治療方式,但是也都失敗了,幹細胞治療讓她現在可以藉由助行器行走,也拿到了駕照。

She told the Sunday Times: ‘This treatment has given me my life back.’
'This is not a word I would use lightly but we have seen profound neurological improvements.’

However, more research is needed to prove the patients are not just experiencing a temporary remission, which does happen in MS.

The neurological condition, which is more common in women than men, usually strikes those in their 20s and 30s and affects 2.5million people worldwide, including 100,000 Britons. It can cause blindness and paralysis, but current drugs are not suitable for all and there is no cure.

The disease occurs when ‘friendly fire’ from the body’s immune system destroys myelin, the fatty protective sheath around nerve fibres in the brain and spinal cord, disrupting the transmission of vital signals.
The Sheffield treatment uses the stem cells to ‘reboot’ the immune system so that it stops attacking the body and brain.

First, a sample of the patient’s blood is taken and stem cells are removed from it and stored.

The patient is then given a high dose of chemotherapy to wipe out their faulty immune system. 

Finally, they are given their stem cells back. As master cells, they are able to form a new, healthy immune system.

The transplant has a one-off cost of around £30,000, similar to the amount spent on some patients’ drugs each year. 

As well as stopping the disease in its tracks the treatment, known as autologous haematopoietic stem cell transplantation, seems to heal damage that has already been done.

A man who was blind in one eye has almost normal vision again. 

A woman in Canada who needed 24-hour care appears free of MS more than a decade after being given a transplant of her own stem cells.

Despite these dramatic improvements, the treatment is not suitable for all patients.

 A US trial on almost 150, reported last month in the Journal of the American Medical Association, showed it to help roughly half the time.

There are also concerns about complications including potentially lethal infections.

Professor Sharrack and colleagues are seeking patients with relapsing-remitting MS, the most common form, for an NHS-funded trial.
目前英國國民保健服務處(NHS)教授 Sharrack 團隊正在募集較規模的實驗。
The MS Society described the Sheffield work as ‘very encouraging’ and said it is eagerly awaiting the results of larger trials.

Read more: http://www.dailymail.co.uk/news/article-2974675/MS-stem-cell-treatment-hailed-miraculous-patients-make-dramatic-recovery.html#ixzz3TF2Zd6ml 


1 則留言:

  1. “New treatments for MS are urgently needed, but as yet there are no stem cell therapies licensed for MS anywhere in the world. This means they aren't yet established as being both safe and effective. This type of stem cell therapy is very aggressive and does carry significant risks, so we would strongly urge caution in seeking this treatment outside of a properly regulated clinical trial."