Potential Role of Vitamin D in Multiple Sclerosis(
中文來囉!!)
A deficiency in vitamin D is currently one of the most studied environmental risk factors for MS and is potentially the most promising in terms of new clinical implications. In particular, this vitamin could alter the immune response taking a positive role in the central nervous system. There are two main types of risk factors for MS: genetic and environmental. In today’s world many genetic predispositions for various conditions have been discovered, and the various environmental triggers identified; making this an exciting time for learning specific ways to change behavior to improve or protect health.
缺乏維他命D是目前對於造成多發性硬化症(MS)的潛在的因子之一. 這種維他命在中樞神經系統中能夠扮演一個改變免疫反應的重要的角色!! 對於多發性硬化症而言, 主要源自兩種風險: 一種是基因上的, 另一種則是環境上的風險... 而學習如何改變環境上的風險(生活飲食習慣)是能夠讓我們更健康的路途之一.
The following environmental factors influence the risk of MS(影響MS的環境風險有):
1. latitude (緯度)
2. past exposure to sun (曬太陽的時間)
3. serum level of vitamin D (血液中維生素D的含量)
Worldwide, latitude has an undeniable effect on the prevalence of MS which occurs with much greater frequency in areas further away from the equator. Lower incidence of the disease is found in tropical regions where the high degree of sunlight is recognized as the correlate. Latitude has an overall influence on the amount of sunlight in a given region making geographical location advantageous. So if we know that the level of exposure to sunlight directly affects the level of vitamin D in our bodies and this vitamin is known as the “sunshine vitamin” where does that leave those of us who live in the northern hemisphere? Does this suggest people even without disease are deficient in vitamin D? Also, the western diet lacks this crucial vitamin providing less than 100 IU a day, falling far below the daily requirement of 2,000 IU/d. It is thought that vitamin D is most likely involved in a number of regulatory activities besides just bone health, and could have a dramatic effect on immune function. Such low average levels of vitamin D raise serious public health issues and there is an urgent need for national health institutes to take preventative measures. With this knowledge should come behavior change, not only for the MS patient but also the general population.
Clinically most MS patients have low levels of vitamin D in their blood and are in a state of deficiency compared to the international norm. A recent study found a direct link between the level of vitamin D circulating in the blood and the disease, without factoring in the effect of latitude or sun exposure. Further research trials are necessary before any firm recommendations can be made but in the meantime, physicians can no longer ignore that many MS patients have a lack of vitamin D, which could be detected through systematic blood tests. Vitamin D supplements are appropriate to restore their levels to within normal range. This should be considered a general medical recommendation simply to increase levels in the blood to the current recommended amount of at least 2,000 IU/d. This would mean taking between 1,000 and 3,000 IU of vitamin D3 (cholecalciferol) on average per day. There are two types of vitamin D: D2 and D3. Vitamin D3 is the healthy kind your body makes when exposed to sunshine. D2 is the synthetic form used in prescriptions and is considered inferior to D3.
臨床上, MS的病人血液中維生素D的含量都偏低, 建議該含量至少維持在2,000 IU/d (IU:國際單位). 也就是說: 每日建議維生素D的食用量為1,000 到 3,000 IU之間, 而食用的維生素D形式要D3(cholecalciferol). 維生素D有兩種形式, D2 and D3, D3也是曬太陽所能夠產生的形式..
Having this knowledge regarding the benefits of vitamin D as well as the current published research indicating the prevalence of vitamin D deficiency; behavioral strategies seem appropriate and can be very safe when discussed with your physician. Since moving to a tropical region is unlikely, the options available are:
safe sun exposure, vitamin supplementation, and a diet with foods rich in vitamin D.
Optimizing sun exposure is a topic in itself and comes with some risk along with conflicting opinions and recommendations from experts in the field though it seems reasonable to get a dose of fresh air and sunshine on days when the weather is in your favor. Some experts recommend exposing your body to sunlight for 15-minutes before applying sunscreen in order to get the benefits from the UV rays which naturally provide the vitamin D needed for good health. Luckily a vitamin D3 supplement can provide the same benefits when given in the appropriate dose to bring blood levels to within normal range.
一般而言, 至少在太陽下曬15分鐘就能夠開始產生身體所需要的維生素D
Before purchasing a supplement you should have a blood test to determine your baseline levels of vitamin D. Your neurologist can then take the results and prescribe the amount of vitamin D3 to bring your levels up to within normal range. MS patients are seen regularly to monitor their disease status and can systematically have blood levels measured. You also may want to search for MS Centers that are running clinical trials to study the effects of Vitamin D on MS and inquire about being a subject.
Vitamin D3 supplements are available in both liquid and capsule form. They can be purchased at any pharmacy for as little as $4.49 for 100 capsules containing 1000.0 IU. Check the label to make sure the primary ingredient is Vitamin D (as cholecalciferol). As mentioned earlier the Western diet is commonly very low in vitamin D but there are good food choices to increase the amount in your diet. Excellent food sources include: oily fish like salmon, mackerel, and sardines; vitamin D-fortified milk and cereals; whole eggs, liver, and beef. A combination of the three available sources of vitamin D is optimal, and purely from a medical point of view, supplementation is unavoidable in order to improve the general health of the MS patient. And with clinical research trials underway all over the globe, supplementation may soon be proven to be neurologically beneficial.
在食物上可以多攝取含有維生素D的食物如: 附有魚油的魚如: 鮭魚, 鯖魚, 沙丁魚, 蛋, 肝, 牛肉, 麥片....
我的治療方法-2 維生素之二三事之維生素D: Potential Role of Vitamin D in Multiple Sclerosis
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