網誌文章搜尋建議

給多發性硬化症MS病友和親友的建議:
如要搜尋站內相關文章可多利用
"搜尋此網誌的文章內容"的功能,這樣就可以快速的找到你想要得資訊而不需要從第一篇開始看了.
有關CCSVI(靜脈血管窄化及手術的資訊)可在相關連結以及相關MS blog內

推薦頻道:Gimmy a break

2015年4月23日 星期四

新藥資訊:Lemtrada 蘭特拉達

多發性硬化症 有新藥救了
 附上Lemtrada 蘭特拉達 藥物經過美國FDA的核准以及藥物使用說明
http://www.fda.gov/downloads/Drugs/DrugSafety/UCM426512.pdf
 附上Lemtrada 蘭特拉達 藥物相關資訊以及說明
http://www.rxlist.com/lemtrada-side-effects-drug-center.htm
以上為重要的連結。


常見的副作用包括:
 皮疹,頭痛,發熱鼻咽炎,噁心尿路感染,疲勞,失眠上呼吸道感染皰疹病毒感染蕁麻疹瘙癢甲狀腺疾病真菌感染關節痛,痛在四肢,背部腹痛,腹瀉鼻竇炎口腔疼痛,麻木刺痛,頭暈腹痛,面色潮紅嘔吐

藥物使用:
Lemtrada蘭特拉達推薦劑量為12毫克/天,2個療程給予靜脈滴注:第一療程12毫克/天 連續5天(60毫克總劑量;二療程12毫克/日 連續3天36毫克總劑量的第一個療程12個月後執行。Lemtrada可以與其他藥物發生相互作用

臨床試驗

對照臨床試驗(研究1研究2,一共有811的MS接收LEMTRADA復發的形式。共有811名患者接受第1個療程治療,789例患者接受治療的第二個療程12個月65為女性,92%是白人


附上原文報導:

SAN ANTONIO - A groundbreaking new treatment for multiple sclerosis is now available in the United States and is being used to treat patients in San Antonio.

The drug Lemtrada was initially denied approval by the U.S. Food and Drug Administration but the decision was reversed several months ago, after a big outcry from the MS patient community.
Lisa Capps was excited to try the new treatment. She'll spend the week hooked up to an intravenous treatment of Lemtrada for about seven hours a day for five days.
However, she believes the time spent will be worth it. Other treatments for MS haven't worked for her and said she believes the new treatment could give a fighting chance.
"This was the newest thing out there and what they call the closest to a cure that we can get to MS right now," said Capps.
Capps was first diagnosed about a year ago, shortly after he daughter was born.
"I have to walk with a cane now and I also have cognitive problems, so I have difficulty thinking, focusing, holding attention," she said.
As the disease progresses, it could lead to vision loss, complete inability to walk, urinary and bowel disfunction, the inability to sense arms and legs, dizziness, loss of balance, and other disabilities.
Treatment with Lemtrada is expected to slow progression of the disease and reduce relapses.
Capp's physician, Dr. Ann Bass, a neurologist and multiple sclerosis specialist at Neurology Center of San Antonio, said Lemtrada works by rebooting the immune system and is similar to rebooting a computer.
She said it wipes out the immune system, then allows it to rebuild over time.
"The immune system kind of rebalance itself and it can last for several years," Bass said.
At first, patients need close monitoring, especially for kidney and thyroid function. During the time the immune system is low, patients require frequent health checks.
However, according to Bass, clinical trials have had ground breaking results
"I have patients in 10 years remission after two years of treatment," she said. " It improves their prognosis and really, most importantly, it just really improves their quality of life."
"It gives me lots of hope because I have a daughter who is 15 months old and I want to be able to keep up with her," said Capps.
Lemtrada is also unique because of the dosing.
According to Bass, other treatments include daily pills or injections several times a week, while Lemtrada is given intravenously for a five-day period the first year and then a three-day period for the second year.
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