MS的另ㄧ個成因:病毒感染

轉載:中央社 :台灣研究：多發性硬化症與帶狀皰疹有關

時間：2011/6/17 11:06 撰稿‧編輯：季　平 　　新聞引據：維基百科 、路透社

北醫醫生康峻宏(網路圖片) 　　路透社今天(17日)報導，台灣的研究人員發現，患 有帶狀皰疹的人比較可能罹患多發性硬化症(multiple sclerosis)，帶狀皰疹的病人在第二年被診斷出多發性硬化症的機率，是其他人的4倍。這項研究並發表在傳染病學期刊(Journal of Infectious Diseases)上。 　　由台北醫學大學附設醫院醫生康峻宏領導的研究小組表示，他們的這項研究並未顯示帶狀皰疹本身會引發多發性硬化症，但是有多項可能的物理過程可以解釋兩者之間的關連。 　　康峻宏說，帶狀皰疹、多發性硬化症都和免疫系統功能崩解有關，帶狀皰疹病毒可能在病人體內引發一系列的免疫反應，而這可能與多發性硬化症相關。 　　根據涵蓋台灣98%人口的保險資料，研究人員發現，超過30萬人發生過帶狀皰疹，其中有不到1萬人後來罹患多發性硬化症；但與非帶狀皰疹病人相比，機率多出將近4倍。不過研究報告的作者也表示，這次的研究對象以漢族為主，因此，研究結果可能不適用於西方人口。 　　帶狀皰疹是由水痘帶狀皰疹病毒引起的急性炎症性皮膚病，一般好發於冬天，過於疲勞導致免疫力下降時會發生此病，患部會有刺痛的感覺。 帶狀疱疹(俗稱「生蛇」或『皮蛇』) 「生蛇」是由引發水痘的病毒再激活所引起的疼痛狀態，此病毒稱為水痘帶狀疱疹病毒。 一旦感染水痘，這種病毒就會進入蟄伏狀態，依附於人體的神經纖維中。

--------------------------
病毒感染引起多發性硬化症也是ㄧ個重要的原因之ㄧ!

Multiple sclerosis linked to shingles

New York - People who get shingles are more likely to also develop multiple sclerosis, with researchers in Taiwan finding that people who developed shingles had four times the risk of being diagnosed with MS within the next year.

But the team led by Jiunn-Horng Kang at Taipei Medical University Hospital warned that their study did not show that shingles itself could cause MS, although there were "several potential mechanisms" that could explain why the two diseases are linked.

"Our findings support the notion that occurrence of MS could be associated with herpes zoster attack," Kang and colleagues wrote in the Journal of Infectious Diseases.

"We found a significantly higher risk for MS within one year of [a] herpes zoster attack compared with the control population."

Shingles is a painful condition caused by reactivation of the virus that causes chicken pox, known as varicella-zoster virus. Once a person has had chicken pox, the virus goes into a dormant state, dwelling in the body's nerve fibres.

Symptoms

However, in some people the virus can reactivate and cause shingles, which usually begins with a burning pain or itch in one location on one side of the body, followed by a rash of fluid-filled blisters.

MS occurs when the protective coating around nerve fibres begins to break down, slowing the brain's communication to the rest of the body. Symptoms include fatigue and problems with balance and muscle co-ordination, as well as memory loss and trouble with logical thinking in some people.

About 2.5 million people have MS worldwide, according to the Multiple Sclerosis Association of America. Most experience their first symptoms between the ages of 15 and 50.

Reviewing a database from the insurer that covers 98% of Taiwan's population, the researchers found more than 300 000 people with shingles. They compared them to nearly 950 000 others with similar characteristics, who didn't have the disease.

Over the course of a year, fewer than one in 10 000 in the group with shingles developed MS - but that was still nearly four times as many as in the group without shingles.

"After adjusting for monthly income and geographic region, the hazard of MS was 3.96 times greater for the study group than controls," the researchers wrote.

Kang said that shingles is associated with disruptions to the immune system, which in turn might trigger MS. Also, a reactivation of the shingles virus may "provoke a series of immune responses in the host which may be linked to MS", Kang said.

The authors cautioned that most people included in the study were Han Chinese, among whom MS occurs relatively infrequently, so the findings might not apply to Western populations.

In addition, the authors did not have information about whether people smoked or drank alcohol, another potential influence on the findings.

"These factors may be confounding to our results and need to be further explored," Kang added.

MS的另ㄧ個成因:病毒感染